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human pancreatic adenocarcinoma cells psn 1  (ATCC)


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    Structured Review

    ATCC human pancreatic adenocarcinoma cells psn 1
    A) Uptake of [ 123 I]Italia_A in <t>PSN-1</t> cells at different time points. B) Efflux of [ 123 I]Italia_A in PSN1 cells. C) Comparison of u ptake and blocking of [ 123 I]Italia_A, B and racemic mix. in PSN-1, cas1, KO cells after 1 hour exposure. D) Comparison of b locking of [ 123 I]Italia_A, B and racemic mix. uptake in PSN-1 cells by panel of PARP inhibitors.
    Human Pancreatic Adenocarcinoma Cells Psn 1, supplied by ATCC, used in various techniques. Bioz Stars score: 95/100, based on 67 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/human pancreatic adenocarcinoma cells psn 1/product/ATCC
    Average 95 stars, based on 67 article reviews
    human pancreatic adenocarcinoma cells psn 1 - by Bioz Stars, 2026-04
    95/100 stars

    Images

    1) Product Images from "[ 123 I]Italia: A PARP-Directed Auger Electron-Emitting Agent for Targeted Radionuclide Therapy of Cancer"

    Article Title: [ 123 I]Italia: A PARP-Directed Auger Electron-Emitting Agent for Targeted Radionuclide Therapy of Cancer

    Journal: bioRxiv

    doi: 10.64898/2026.03.13.711622

    A) Uptake of [ 123 I]Italia_A in PSN-1 cells at different time points. B) Efflux of [ 123 I]Italia_A in PSN1 cells. C) Comparison of u ptake and blocking of [ 123 I]Italia_A, B and racemic mix. in PSN-1, cas1, KO cells after 1 hour exposure. D) Comparison of b locking of [ 123 I]Italia_A, B and racemic mix. uptake in PSN-1 cells by panel of PARP inhibitors.
    Figure Legend Snippet: A) Uptake of [ 123 I]Italia_A in PSN-1 cells at different time points. B) Efflux of [ 123 I]Italia_A in PSN1 cells. C) Comparison of u ptake and blocking of [ 123 I]Italia_A, B and racemic mix. in PSN-1, cas1, KO cells after 1 hour exposure. D) Comparison of b locking of [ 123 I]Italia_A, B and racemic mix. uptake in PSN-1 cells by panel of PARP inhibitors.

    Techniques Used: Comparison, Blocking Assay

    A) IC 50 in PSN-1 cells (IC 50 : 2.85 nM, 95%CI: 1.98 nM-4.08 nM, R squared: 0.984 (of [ 123 I]Italia), IC 50 : 1.36 nM, 95%CI: 0.5 nM −3.67 nM, R squared: 0.899 of [ 123 I]Italia_B), IC50: 2.96 nM, 95%CI: 1.1 nM-7.9 nM, R 2 : 0.970 (of racemic mix.). B ) Cell fractionation of [ 123 I]Italia_A in PSN-1 cells: western blot. C) Cell fractionation of [ 123 I]Italia_A in different cell lines. In membrane bound fraction. D) Cytoplasm soluble fraction. E) Chromatin soluble fraction. F) Nuclear soluble fraction.
    Figure Legend Snippet: A) IC 50 in PSN-1 cells (IC 50 : 2.85 nM, 95%CI: 1.98 nM-4.08 nM, R squared: 0.984 (of [ 123 I]Italia), IC 50 : 1.36 nM, 95%CI: 0.5 nM −3.67 nM, R squared: 0.899 of [ 123 I]Italia_B), IC50: 2.96 nM, 95%CI: 1.1 nM-7.9 nM, R 2 : 0.970 (of racemic mix.). B ) Cell fractionation of [ 123 I]Italia_A in PSN-1 cells: western blot. C) Cell fractionation of [ 123 I]Italia_A in different cell lines. In membrane bound fraction. D) Cytoplasm soluble fraction. E) Chromatin soluble fraction. F) Nuclear soluble fraction.

    Techniques Used: Cell Fractionation, Western Blot, Membrane

    A) Clonogenic survival of PSN-1 and PARP1 knock out cells (PSN-1 PARP1−/− ) after exposure of cells for 1h to [ 123 I]Italia_rac, and the separated enantiomers of [ 123 I]Italia_A or _B (0-500 kBq in 2 mL of growth medium). B) Clonogenic survival of various cell lines after exposure of cells for 1h to [ 123 I]Italia_A (0-500 kBq in 2mL of growth medium).
    Figure Legend Snippet: A) Clonogenic survival of PSN-1 and PARP1 knock out cells (PSN-1 PARP1−/− ) after exposure of cells for 1h to [ 123 I]Italia_rac, and the separated enantiomers of [ 123 I]Italia_A or _B (0-500 kBq in 2 mL of growth medium). B) Clonogenic survival of various cell lines after exposure of cells for 1h to [ 123 I]Italia_A (0-500 kBq in 2mL of growth medium).

    Techniques Used: Knock-Out



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    human pancreatic adenocarcinoma cells psn 1  (ATCC)
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    ATCC human pancreatic adenocarcinoma cells psn 1
    A) Uptake of [ 123 I]Italia_A in <t>PSN-1</t> cells at different time points. B) Efflux of [ 123 I]Italia_A in PSN1 cells. C) Comparison of u ptake and blocking of [ 123 I]Italia_A, B and racemic mix. in PSN-1, cas1, KO cells after 1 hour exposure. D) Comparison of b locking of [ 123 I]Italia_A, B and racemic mix. uptake in PSN-1 cells by panel of PARP inhibitors.
    Human Pancreatic Adenocarcinoma Cells Psn 1, supplied by ATCC, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/human pancreatic adenocarcinoma cells psn 1/product/ATCC
    Average 95 stars, based on 1 article reviews
    human pancreatic adenocarcinoma cells psn 1 - by Bioz Stars, 2026-04
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    psn 1  (ATCC)
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    ATCC psn 1
    Effects of circ72309 overexpression on cellular function in gemcitabine-resistant cell lines. (A) Vector schema for overexpression of circ72309. (B) Dose-response curves of gemcitabine in GR_NC and GR_circ72309OE clones. GR_circ72309OE clones showed a concentration-dependent decrease in viability with a typical sigmoidal fitting (IC 50 values: GR3, 13.3 ng/ml, R 2 =0.974; GR8, 130 ng/ml, R 2 =0.951; GR10, 16.9 ng/ml, R 2 =0.984), whereas GR_NC cells retained high viability even at maximal gemcitabine concentrations, consistent with the resistant phenotype. Fitted curves are shown as solid lines, while resistant clone values without a typical sigmoidal decline are represented as dashed lines. (C) MTT assays were used to assess the effects of si-circ72309 in PC cell lines <t>(MIAPaCa-2,</t> <t>PSN-1</t> and Panc-1). Dose-response curves were analyzed using non-linear regression with a four-parameter logistic model; all fitted curves showed excellent agreement with the experimental data (R 2 >0.95). Fitted curves are shown as solid lines. (D) Apoptosis assays following treatment with 20 ng/ml gemcitabine. * P<0.05. circRNA, circular RNA; PC, pancreatic cancer; GR, gemcitabine resistant; NC, negative control; siRNA, small interfering RNA.
    Psn 1, supplied by ATCC, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/psn 1/product/ATCC
    Average 90 stars, based on 1 article reviews
    psn 1 - by Bioz Stars, 2026-04
    90/100 stars
    		  Buy from Supplier
    psn1  (ATCC)
    95
    ATCC psn1
    Effects of circ72309 overexpression on cellular function in gemcitabine-resistant cell lines. (A) Vector schema for overexpression of circ72309. (B) Dose-response curves of gemcitabine in GR_NC and GR_circ72309OE clones. GR_circ72309OE clones showed a concentration-dependent decrease in viability with a typical sigmoidal fitting (IC 50 values: GR3, 13.3 ng/ml, R 2 =0.974; GR8, 130 ng/ml, R 2 =0.951; GR10, 16.9 ng/ml, R 2 =0.984), whereas GR_NC cells retained high viability even at maximal gemcitabine concentrations, consistent with the resistant phenotype. Fitted curves are shown as solid lines, while resistant clone values without a typical sigmoidal decline are represented as dashed lines. (C) MTT assays were used to assess the effects of si-circ72309 in PC cell lines <t>(MIAPaCa-2,</t> <t>PSN-1</t> and Panc-1). Dose-response curves were analyzed using non-linear regression with a four-parameter logistic model; all fitted curves showed excellent agreement with the experimental data (R 2 >0.95). Fitted curves are shown as solid lines. (D) Apoptosis assays following treatment with 20 ng/ml gemcitabine. * P<0.05. circRNA, circular RNA; PC, pancreatic cancer; GR, gemcitabine resistant; NC, negative control; siRNA, small interfering RNA.
    Psn1, supplied by ATCC, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/psn1/product/ATCC
    Average 95 stars, based on 1 article reviews
    psn1 - by Bioz Stars, 2026-04
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    Image Search Results


    A) Uptake of [ 123 I]Italia_A in PSN-1 cells at different time points. B) Efflux of [ 123 I]Italia_A in PSN1 cells. C) Comparison of u ptake and blocking of [ 123 I]Italia_A, B and racemic mix. in PSN-1, cas1, KO cells after 1 hour exposure. D) Comparison of b locking of [ 123 I]Italia_A, B and racemic mix. uptake in PSN-1 cells by panel of PARP inhibitors.

    Journal: bioRxiv

    Article Title: [ 123 I]Italia: A PARP-Directed Auger Electron-Emitting Agent for Targeted Radionuclide Therapy of Cancer

    doi: 10.64898/2026.03.13.711622

    Figure Lengend Snippet: A) Uptake of [ 123 I]Italia_A in PSN-1 cells at different time points. B) Efflux of [ 123 I]Italia_A in PSN1 cells. C) Comparison of u ptake and blocking of [ 123 I]Italia_A, B and racemic mix. in PSN-1, cas1, KO cells after 1 hour exposure. D) Comparison of b locking of [ 123 I]Italia_A, B and racemic mix. uptake in PSN-1 cells by panel of PARP inhibitors.

    Article Snippet: Human pancreatic adenocarcinoma cells (PSN-1), and human prostate cancer cells (PC-3) were purchased from ATCC; the murine breast cancer cell line 4T1 was a kind gift from prof. Nicola Sibson, Department of Oncology, University of Oxford.

    Techniques: Comparison, Blocking Assay

    A) IC 50 in PSN-1 cells (IC 50 : 2.85 nM, 95%CI: 1.98 nM-4.08 nM, R squared: 0.984 (of [ 123 I]Italia), IC 50 : 1.36 nM, 95%CI: 0.5 nM −3.67 nM, R squared: 0.899 of [ 123 I]Italia_B), IC50: 2.96 nM, 95%CI: 1.1 nM-7.9 nM, R 2 : 0.970 (of racemic mix.). B ) Cell fractionation of [ 123 I]Italia_A in PSN-1 cells: western blot. C) Cell fractionation of [ 123 I]Italia_A in different cell lines. In membrane bound fraction. D) Cytoplasm soluble fraction. E) Chromatin soluble fraction. F) Nuclear soluble fraction.

    Journal: bioRxiv

    Article Title: [ 123 I]Italia: A PARP-Directed Auger Electron-Emitting Agent for Targeted Radionuclide Therapy of Cancer

    doi: 10.64898/2026.03.13.711622

    Figure Lengend Snippet: A) IC 50 in PSN-1 cells (IC 50 : 2.85 nM, 95%CI: 1.98 nM-4.08 nM, R squared: 0.984 (of [ 123 I]Italia), IC 50 : 1.36 nM, 95%CI: 0.5 nM −3.67 nM, R squared: 0.899 of [ 123 I]Italia_B), IC50: 2.96 nM, 95%CI: 1.1 nM-7.9 nM, R 2 : 0.970 (of racemic mix.). B ) Cell fractionation of [ 123 I]Italia_A in PSN-1 cells: western blot. C) Cell fractionation of [ 123 I]Italia_A in different cell lines. In membrane bound fraction. D) Cytoplasm soluble fraction. E) Chromatin soluble fraction. F) Nuclear soluble fraction.

    Article Snippet: Human pancreatic adenocarcinoma cells (PSN-1), and human prostate cancer cells (PC-3) were purchased from ATCC; the murine breast cancer cell line 4T1 was a kind gift from prof. Nicola Sibson, Department of Oncology, University of Oxford.

    Techniques: Cell Fractionation, Western Blot, Membrane

    A) Clonogenic survival of PSN-1 and PARP1 knock out cells (PSN-1 PARP1−/− ) after exposure of cells for 1h to [ 123 I]Italia_rac, and the separated enantiomers of [ 123 I]Italia_A or _B (0-500 kBq in 2 mL of growth medium). B) Clonogenic survival of various cell lines after exposure of cells for 1h to [ 123 I]Italia_A (0-500 kBq in 2mL of growth medium).

    Journal: bioRxiv

    Article Title: [ 123 I]Italia: A PARP-Directed Auger Electron-Emitting Agent for Targeted Radionuclide Therapy of Cancer

    doi: 10.64898/2026.03.13.711622

    Figure Lengend Snippet: A) Clonogenic survival of PSN-1 and PARP1 knock out cells (PSN-1 PARP1−/− ) after exposure of cells for 1h to [ 123 I]Italia_rac, and the separated enantiomers of [ 123 I]Italia_A or _B (0-500 kBq in 2 mL of growth medium). B) Clonogenic survival of various cell lines after exposure of cells for 1h to [ 123 I]Italia_A (0-500 kBq in 2mL of growth medium).

    Article Snippet: Human pancreatic adenocarcinoma cells (PSN-1), and human prostate cancer cells (PC-3) were purchased from ATCC; the murine breast cancer cell line 4T1 was a kind gift from prof. Nicola Sibson, Department of Oncology, University of Oxford.

    Techniques: Knock-Out

    Effects of circ72309 overexpression on cellular function in gemcitabine-resistant cell lines. (A) Vector schema for overexpression of circ72309. (B) Dose-response curves of gemcitabine in GR_NC and GR_circ72309OE clones. GR_circ72309OE clones showed a concentration-dependent decrease in viability with a typical sigmoidal fitting (IC 50 values: GR3, 13.3 ng/ml, R 2 =0.974; GR8, 130 ng/ml, R 2 =0.951; GR10, 16.9 ng/ml, R 2 =0.984), whereas GR_NC cells retained high viability even at maximal gemcitabine concentrations, consistent with the resistant phenotype. Fitted curves are shown as solid lines, while resistant clone values without a typical sigmoidal decline are represented as dashed lines. (C) MTT assays were used to assess the effects of si-circ72309 in PC cell lines (MIAPaCa-2, PSN-1 and Panc-1). Dose-response curves were analyzed using non-linear regression with a four-parameter logistic model; all fitted curves showed excellent agreement with the experimental data (R 2 >0.95). Fitted curves are shown as solid lines. (D) Apoptosis assays following treatment with 20 ng/ml gemcitabine. * P<0.05. circRNA, circular RNA; PC, pancreatic cancer; GR, gemcitabine resistant; NC, negative control; siRNA, small interfering RNA.

    Journal: International Journal of Oncology

    Article Title: Circ72309 modulates gemcitabine metabolism and gemcitabine sensitivity in pancreatic cancer: Serum Circ72309 levels as a potential predictor of treatment response

    doi: 10.3892/ijo.2026.5849

    Figure Lengend Snippet: Effects of circ72309 overexpression on cellular function in gemcitabine-resistant cell lines. (A) Vector schema for overexpression of circ72309. (B) Dose-response curves of gemcitabine in GR_NC and GR_circ72309OE clones. GR_circ72309OE clones showed a concentration-dependent decrease in viability with a typical sigmoidal fitting (IC 50 values: GR3, 13.3 ng/ml, R 2 =0.974; GR8, 130 ng/ml, R 2 =0.951; GR10, 16.9 ng/ml, R 2 =0.984), whereas GR_NC cells retained high viability even at maximal gemcitabine concentrations, consistent with the resistant phenotype. Fitted curves are shown as solid lines, while resistant clone values without a typical sigmoidal decline are represented as dashed lines. (C) MTT assays were used to assess the effects of si-circ72309 in PC cell lines (MIAPaCa-2, PSN-1 and Panc-1). Dose-response curves were analyzed using non-linear regression with a four-parameter logistic model; all fitted curves showed excellent agreement with the experimental data (R 2 >0.95). Fitted curves are shown as solid lines. (D) Apoptosis assays following treatment with 20 ng/ml gemcitabine. * P<0.05. circRNA, circular RNA; PC, pancreatic cancer; GR, gemcitabine resistant; NC, negative control; siRNA, small interfering RNA.

    Article Snippet: In the present study, three human PC cell lines: MIAPaCa-2 (RRID: CVCL_0428) purchased from the Japan Cancer Research Resources Bank, Panc-1 (RRID: CVCL_0480) purchased from the American Type Culture Collection and PSN-1 (RRID: CVCL_1644) obtained from the European Collection of Authenticated Cell Culture.

    Techniques: Over Expression, Cell Function Assay, Plasmid Preparation, Clone Assay, Concentration Assay, Negative Control, Small Interfering RNA